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Francis Crick Quotes

Francis Crick Quotes & Quotations
Francis Crick
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  • 1
    A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement. Francis-CrickFrancis Crick
  • 2
    A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here. Francis-CrickFrancis Crick
  • 3
    Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets. Francis-CrickFrancis Crick
  • 4
    By using polymers of different composition and assuming a triplet code one can deduce limited information about the composition of certain triplets. Francis-CrickFrancis Crick
  • 5
    Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap. Francis-CrickFrancis Crick
  • 6
    For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few. Francis-CrickFrancis Crick
  • 7
    If poly A is added to poly U, to form a double or triple helix, the combination is inactive. Francis-CrickFrancis Crick
  • 8
    If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it. Francis-CrickFrancis Crick
  • 9
    If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place. Francis-CrickFrancis Crick
  • 10
    It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code. Francis-CrickFrancis Crick
  • 11
    It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule. Francis-CrickFrancis Crick
  • 12
    It seems likely that most if not all the genetic information in any organism is carried by nucleic acid - usually by DNA, although certain small viruses use RNA as their genetic material. Francis-CrickFrancis Crick
  • 13
    It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code. Francis-CrickFrancis Crick
  • 14
    The genetic code describes the way in which a sequence of twenty or more things is determined by a sequence of four things of a different type. Francis-CrickFrancis Crick
  • 15
    The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one amino acid. However one would certainly expect such triplets to be in a minority. Francis-CrickFrancis Crick
  • 16
    This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map. Francis-CrickFrancis Crick
  • 17
    Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid. Francis-CrickFrancis Crick
  • 18
    We are sometimes asked what the result would be if we put four +'s in one gene. To answer this my colleagues have recently put together not merely four but six +'s. Francis-CrickFrancis Crick
  • 19
    We've discovered the secret of life. Francis-CrickFrancis Crick